Fibroblast phenotypes in different lung diseases

Fibroblast phenotypes in different lung diseases

BACKGROUND The "seed and soil" hypothesis emphasizes the importance of interactions between tumor cells and their microenvironment. CAFs (Cancer associated fibroblasts) are important components of the tumor microenvironment. They were widely involved in cancer cells growth and metastasis. Fibroblasts may also play a role in inflammatory disease. The phenotype conversion of fibroblasts in lung d...

Author ' s response to reviews Title : Fibroblast Phenotypes in Different Lung Diseases

Different phenotypes in dysferlinopathy.

Key words: dysferlin, limb-girdle muscular dystrophy, Miyoshi myopathy Limb-girdle muscular dystrophy (LGMD) is a heterogeneous group of disorders and consists of 9 autosomal recessive types (1-9), and 5 autosomal dominant types (10, 1 1). Recently two different clinical forms of muscular dystro-phy, LGMD2B and Miyoshi myopathy have been shown to have a dysferlin defect (12-14), which is a prot...

Asbestos-related Lung Diseases: A Brief Update

Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assum...

Mechanical regulation of cardiac fibroblast profibrotic phenotypes

Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts, characterized by proliferation, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smooth muscle α-actin. The mechanical properties of myocardium change regionally and ove...